Article
Deletion of parental GST genes as a possible susceptibility factor in the etiology of infant leukemia.
Leukemia research - 1 Nov 2000
Garte S, Taioli E, Crosti F, Sainati L, Barisone E, Luciani M, Jankovic M, Biondi A G
Abstract excerpt
Infant leukemia below the age of 12 months is a rare disease that exhibits a high frequency of 11q23 rearrangements. We assessed the presence of polymorphisms in several metabolic genes in 23 families of infants diagnosed with leukemia under 12 months of age in Italy. When polymorphism frequencies were calculated within families, frequencies of GST gene deletions were significantly higher than expected only among...
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