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Article

Lung resistance-related protein/major vault protein and vaults in multidrug-resistant cancer

1 Nov 2000

Abstract excerpt

Tumor cells that are insensitive to anticancer drugs frequently have a multidrug-resistant (MDR) phenotype. Proteins that can be involved in this phenomenon are transport-associated proteins such as P-glycoprotein, multidrug-resistance protein 1, breast cancer resistance protein, and lung resistance-related protein (LRP). LRP was identified as the major vault protein (MVP), the main component of multimeric vault...

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PMID: 11085454
DOI: 10.1097/00001622-200011000-00007

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