Article
Vacuolar H(+)-ATPase plays a crucial role in growth and phenotypic modulation of myofibroblasts in cultured human saphenous vein.
Circulation - 7 Nov 2000
Otani H, Yamamura T, Nakao Y, Hattori R, Fujii H, Ninomiya H, Kido M, Kawaguchi H, Osako M, Imamura H, Ohta T, Ohkuma S
Abstract excerpt
BACKGROUND: The molecular mechanism of neointimal hyperplasia after vein graft surgery remains elusive. Vacuolar H(+)-ATPase (V-ATPase) is involved in intracellular trafficking and may play a crucial role in neointimal cell growth. METHODS AND RESULTS: Cultured human saphenous vein segments developed neointimal formation within 10 days. Neointimal cells were positive for vimentin and alpha-smooth muscle actin but...
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