Article
Early expression of iepsilon, CD23 (FcepsilonRII), IL-4Ralpha, and IgE in the human fetus.
The Journal of allergy and clinical immunology - 1 Nov 2000
Lima J O, Zhang L, Atkinson T P, Philips J, Dasanayake A P, Schroeder H W
Abstract excerpt
BACKGROUND: A major predictor of childhood atopy is the concentration of IgE in the cord blood, but whether the source of cord blood IgE is maternal or fetal remains unclear. OBJECTIVE: We sought to determine the pattern of in situ IgE production during ontogeny. METHODS: Ninety-seven fetal, 142 natal, and 96 childhood samples were analyzed by using reverse transcription PCR for transcription of VDJCepsilon,...
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