Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The zona pellucida-initiated acrosome reaction: defect due to mutations in the sperm glycine receptor/Cl(-) channel.

Developmental biology - 1 Nov 2000

Sato Y, Son J H, Tucker R P, Meizel S

Abstract excerpt

The mammalian sperm acrosome reaction (AR) is essential to fertilization, and the egg zona pellucida (ZP) is generally believed to be an in vivo initiator of the fertilizing sperm AR. Previously a neuronal glycine receptor/Cl(-) channel (GlyR) was detected on the plasma membrane of mammalian sperm and earlier pharmacological studies suggested that this receptor/channel is important to the ZP-initiated AR. Here,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcimycin
Share to Chloride Channels
Share to Glycine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Protein Subunits

Share to Receptors, Glycine

Share to Sperm Motility

Share to Spermatozoa

Share to Testis

Source

Identifiers

PMID: 11076688
DOI: 10.1006/dbio.2000.9882

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

The zona pellucida-initiated acrosome reaction: defect due to mutations in the sperm glycine receptor/Cl(-) channel.PMID 11076688Read ↗

Studies of sperm from mutant mice suggesting that two neurotransmitter receptors are important to the zona pellucida-initiated acrosome reaction.Semantic proximity Read ↗

Requirement of Phospholipase Cδ4 for the Zona Pellucida-Induced Acrosome ReactionSemantic proximity Read ↗

Activation of mouse sperm T-type Ca <sup>2+</sup> channels by adhesion to the egg zona pellucidaSemantic proximity Read ↗

Capacitation of mouse sperm is modulated by gamma-aminobutyric acid (GABA) concentrationSemantic proximity Read ↗

A delayed sperm penetration of cumulus layers by disruption of acrosin gene in rats†Semantic proximity Read ↗

An intact acrosome is required for the chemotactic response to progesterone in mouse spermatozoaSemantic proximity Read ↗

Sperm from mice carrying a targeted mutation of the acrosin gene can penetrate the oocyte zona pellucida and effect fertilization.Semantic proximity Read ↗

Binding of Arylsulfatase A to Mouse Sperm Inhibits Gamete Interaction and Induces the Acrosome Reaction1Semantic proximity Read ↗

Roles of heterotrimeric and monomeric G proteins in sperm-induced activation of mouse eggsSemantic proximity Read ↗

Control of the low voltage-activated calcium channel of mouse sperm by egg ZP3 and by membrane hyperpolarization during capacitationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.