Degradation of Heme in Gram-Negative Bacteria: the Product of the <i>hemO</i> Gene of Neisseriae Is a Heme Oxygenase

Abstract excerpt

A full-length heme oxygenase gene from the gram-negative pathogen Neisseria meningitidis was cloned and expressed in Escherichia coli. Expression of the enzyme yielded soluble catalytically active protein and caused accumulation of biliverdin within the E. coli cells. The purified HemO forms a 1:1 complex with heme and has a heme protein spectrum similar to that previously reported for the purified heme oxygenase...

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