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Identification of an <i>Escherichia coli</i> O157:H7 heme oxygenase with tandem functional repeats

7 Nov 2005

Abstract excerpt

Heme oxygenases (HOs) catalyze the oxidation of heme to biliverdin, carbon monoxide (CO), and free iron. Iron acquisition is critical for invading microorganisms to enable survival and growth. Here we report the crystal structure of ChuS, which displays a previously uncharacterized fold and is unique compared with other characterized HOs. Despite only 19% sequence identity between the N- and C-terminal halves,...

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PMID: 16275907
DOI: 10.1073/pnas.0504289102

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