Article
[The heterozygous effect of X-ray or ENU-induced null-mutant Adh alleles on alcohol tolerance of Drosophila melanogaster].
Yi chuan xue bao = Acta genetica Sinica - 1 Jan 2000
Tong G L, Lin Z X, Jiang J C
Abstract excerpt
To study the mechanisms of partial dominance, 12 intragenic alcohol dehydrogenase null mutations (Adhn) in Drosophila melanogaster were used as a model system. These known sequenced mutations, either single base substitutions or small intragenic deletions (9-16 bp) were analyzed for peptide production, dimer formation and enzymatic activity of the heterodimer. Multiple mechanisms leading to partial enzyme...
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