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Article

Recombinant adeno-associated virus vector-based gene transfer for defects in oxidative metabolism.

Human gene therapy - 10 Oct 2000

Owen R I V, Lewin A P, Peel A, Wang J, Guy J, Hauswirth W W, Stacpoole P W, Flotte T R

Abstract excerpt

Defects in oxidative metabolism may be caused by mutations either in nuclear genes or in mitochondrial DNA (mtDNA). We tested the hypothesis that recombinant adeno-associated virus (rAAV) could be used to complement mtDNA mutations. AAV vector constructs were designed to express the reporter gene encoding green fluorescent protein (GFP), fused to a targeting presequence that directed GFP to be translocated into...

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Source

Identifiers

PMID: 11044909
DOI: 10.1089/104303400750001381

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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