Article
High throughput detection of drug-metabolizing enzyme polymorphisms by allele-specific fluorogenic 5' nuclease chain reaction assay.
Biological & pharmaceutical bulletin - 1 Oct 2000
Hiratsuka M, Agatsuma Y, Omori F, Narahara K, Inoue T, Kishikawa Y, Mizugaki M
Abstract excerpt
We have developed an allele-specific fluorogenic 5' nuclease chain reaction assay for detecting polymorphisms in the following human drug-metabolizing enzyme genes: CYP2C9 (CYP2C9*2 and *3), CYP2C19 (CYP2C19*2 and *3), CYP2D6 (CYP2D6*4, *10, *14, *18, and *21(C8)), N-acetyltransferase 2 (NAT2*5B,...
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