Article
Genetic polymorphisms influence variability in benzene metabolism in humans.
Pharmacogenetics - 1 Aug 1999
Rossi A M, Guarnieri C, Rovesti S, Gobba F, Ghittori S, Vivoli G, Barale R
Abstract excerpt
The role of genetic polymorphism in modulating urinary excretion of two benzene metabolites, i.e. trans,trans-muconic acid (t,t-MA) and S-phenylmercapturic acid (PMA), has been investigated in 59 non-smoking city bus drivers, professionally exposed to benzene via vehicle exhausts. Exposure to benzene was determined by personal passive samplers (mean +/- SD = 82.2 +/- 25.6 micrograms/m3), while internal dose and...
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