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Article

Evaluation of global DNA hypomethylation in human colon cancer tissues by immunohistochemistry and image analysis

1 Nov 2000

Abstract excerpt

BACKGROUND: Global hypomethylation of DNA is frequently observed in human tumours. This alteration is detected in early adenomas in colorectal tumorigenesis. Information is currently acquired after extraction of DNA from tissues, digestion with nucleases, and analysis by reverse phase chromatography, or treatment with restriction enzymes followed by gel electrophoresis analysis and Southern hybridisation with...

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Share to Digestive system and related health
Share to Epigenetics and DNA Methylation
Share to Genetic factors in colorectal cancer

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PMID: 11034586
DOI: 10.1136/gut.47.5.689

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