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Article

Identification of viral genomic elements responsible for rabies virus neuroinvasiveness

1 Nov 2004

Abstract excerpt

Attenuated tissue culture-adapted and natural street rabies virus (RV) strains differ greatly in their neuroinvasiveness. To identify the elements responsible for the ability of an RV to enter the CNS from a peripheral site and to cause lethal neurological disease, we constructed a full-length cDNA clone of silver-haired bat-associated RV (SHBRV) strain 18 and exchanged the genes encoding RV proteins and genomic...

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PMID: 15520387
DOI: 10.1073/pnas.0407289101

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