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Article

Measuring shifts in function and evolutionary opportunity using variability profiles: a case study of the globins.

Journal of molecular evolution - 1 Sept 2000

Naylor G J, Gerstein M

Abstract excerpt

Variability profiles measured over a set of aligned sequences can be used to estimate evolutionary freedom to vary. Differences in variability profiles between clades can be used to identify shifts in function at the molecular level. We demonstrate such a shift between the alpha and beta subunits of hemoglobin. We also show that the variability profiles for myoglobin are different between whales and primates and...

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Identifiers

PMID: 11029067
DOI: 10.1007/s002390010084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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