Article
Disease-associated mutations in SOD1 are impervious to dominant positive or negative effects.
Biochemical and biophysical research communications - 5 Oct 2000
Hall J R, Strathdee C A
Abstract excerpt
The familial form of amyotrophic lateral sclerosis is caused by mutations in the SOD1 gene encoding the cytosolic antioxidant enzyme Cu,Zn superoxide dismutase. Although there is no clear correlation between disease and dismutating catalytic activity among the various disease-associated SOD1 alleles, all of the known missense mutations significantly alter the half-life of the encoded polypeptides. Using transient...
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