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Article

Impaired post-translational folding of familial ALS-linked Cu, Zn superoxide dismutase mutants.

The EMBO journal - 7 Feb 2007

Bruns Cami K, Kopito Ron R

Abstract excerpt

Over 110 structurally diverse missense mutations in the superoxide dismutase (SOD1) gene have been linked to the pathogenesis of familial amyotrophic lateral sclerosis (FALS), yet the mechanism by which these lead to cytotoxicity still remains unknown. We have synthesized wild-type and mutant SOD1 in synchronized cell-free reticulocyte extracts replete with the full complement of molecular chaperones and folding...

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Share to Amyotrophic Lateral Sclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17255946
DOI: 10.1038/sj.emboj.7601528
PMCID: PMC1794386

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Impaired post-translational folding of familial ALS-linked Cu, Zn superoxide dismutase mutants.PMID 17255946Read ↗

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