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Article

Constitutive expression of a complement-like protein in toll and JAK gain-of-function mutants of Drosophila.

Proceedings of the National Academy of Sciences of the United States of America - 10 Oct 2000

Lagueux M, Perrodou E, Levashina E A, Capovilla M, Hoffmann J A

Abstract excerpt

We show that Drosophila expresses four genes encoding proteins with significant similarities with the thiolester-containing proteins of the complement C3/alpha(2)-macroglobulin superfamily. The genes are transcribed at a low level during all stages of development, and their expression is markedly up-regulated after an immune challenge. For one of these genes, which is predominantly expressed in the larval fat...

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Identifiers

PMID: 11027343
DOI: 10.1073/pnas.97.21.11427
PMCID: PMC17216

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