Article
Arginine-rich regions mediate the RNA binding and regulatory activities of the protein encoded by the Drosophila melanogaster suppressor of sable gene.
Molecular and cellular biology - 1 Nov 2000
Turnage M A, Brewer-Jensen P, Bai W L, Searles L L
Abstract excerpt
The Drosophila melanogaster suppressor of sable gene, su(s), encodes a novel, 150-kDa nuclear RNA binding protein, SU(S), that negatively regulates RNA accumulation from mutant alleles of other genes that have transposon insertions in the 5' transcribed region. In this study, we delineated the RNA binding domain of SU(S) and evaluated its relevance to SU(S) function in vivo. As a result, we have defined two...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Arginine
- Base Sequence
- Binding Sites
- Blotting, Western
- Chromosomes
- DNA, Complementary
- Drosophila Proteins
- Drosophila melanogaster
- Immunohistochemistry
- Models, Genetic
- Molecular Sequence Data