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Article

Evidence for splice site pairing via intron definition in Schizosaccharomyces pombe.

Molecular and cellular biology - 1 Nov 2000

Romfo C M, Alvarez C J, van Heeckeren W J, Webb C J, Wise J A

Abstract excerpt

Schizosaccharomyces pombe pre-mRNAs are generally multi-intronic and share certain features with pre-mRNAs from Drosophila melanogaster, in which initial splice site pairing can occur via either exon or intron definition. Here, we present three lines of evidence suggesting that, despite these similarities, fission yeast splicing is most likely restricted to intron definition. First, mutating either or both splice...

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Identifiers

PMID: 11027266
DOI: 10.1128/MCB.20.21.7955-7970.2000
PMCID: PMC86406

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for splice site pairing via intron definition in Schizosaccharomyces pombe.PMID 11027266Read ↗

Activation of a cryptic 5' splice site by U1 snRNA.Semantic proximity Read ↗

Both the polypyrimidine tract and the 3' splice site function prior to the first step of splicing in fission yeast.Semantic proximity Read ↗

Prp4 Kinase Grants the License to Splice: Control of Weak Splice Sites during Spliceosome Activation.Semantic proximity Read ↗

A genetic screen in C. elegans reveals roles for KIN17 and PRCC in maintaining 5' splice site identity.Semantic proximity Read ↗

Mechanisms of intron loss and gain in the fission yeast Schizosaccharomyces.Semantic proximity Read ↗

Cwf16p Associating with the Nineteen Complex Ensures Ordered Exon Joining in Constitutive Pre-mRNA Splicing in Fission Yeast.Semantic proximity Read ↗

A U1-U2 snRNP interaction network during intron definition.Semantic proximity Read ↗

Intron definition in splicing of small Drosophila introns.Semantic proximity Read ↗

Mutations at the 3' splice site can be suppressed by compensatory base changes in U1 snRNA in fission yeast.Semantic proximity Read ↗

Mutation in the U2 snRNA influences exon interactions of U5 snRNA loop 1 during pre-mRNA splicing.Semantic proximity Read ↗

A two-step mechanism for 5' and 3' splice-site pairing.Semantic proximity Read ↗

RS domains contact splicing signals and promote splicing by a common mechanism in yeast through humans.Semantic proximity Read ↗

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