Article
Route of monocyte differentiation determines their cytokine production profile: CD40 ligation induces interleukin 10 expression.
Cytokine - 1 Oct 2000
Foey A D, Feldmann M, Brennan F M
Abstract excerpt
Interleukin 10 is a potent anti-inflammatory and immunomodulatory cytokine. Little is known regarding its induction in monocytes/macrophages, however LPS, a reproducible trigger of IL-10, is augmented by direct contact with T cells. In this context, the role of CD40-ligation is investigated. In the rheumatoid synovium, IL-10 is produced by tissue macrophages. Monocytes primed with M-CSF, a cytokine present in...
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