Article
Alcoholics with the dopamine receptor DRD2 A1 allele have lower platelet monoamine oxidase-B activity than those with the A2 allele: a preliminary study.
Alcohol and alcoholism (Oxford, Oxfordshire) - 1 Jan 2000
Eriksson M, Berggren U, Blennow K, Fahlke C, Månsson J E, Balldin J
Abstract excerpt
Low platelet monoamine oxidase B (MAO-B) activity and the presence of the Taq1 A1 allele of the dopamine D2 receptor (DRD2) gene have independently been proposed as 'biological/genetic' markers for alcoholism. In the present study, the relationship between these two markers was investigated in a group of socially stable Caucasian middle-aged men with a mean (+/-SD) daily ethanol consumption of 85 +/- 57 g. The...
Topics
- Adult
- Aged
- Alcoholism
- Alleles
- Analysis of Variance
- Blood Platelets
- Humans
- Male
- Middle Aged
- Monoamine Oxidase
- Polymorphism, Genetic
- Receptors, Dopamine D2
