Article
Antagonism between C/EBPbeta and FOG in eosinophil lineage commitment of multipotent hematopoietic progenitors.
Genes & development - 1 Oct 2000
Querfurth E, Schuster M, Kulessa H, Crispino J D, Döderlein G, Orkin S H, Graf T, Nerlov C
Abstract excerpt
The commitment of multipotent cells to particular developmental pathways requires specific changes in their transcription factor complement to generate the patterns of gene expression characteristic of specialized cell types. We have studied the role of the GATA cofactor Friend of GATA (FOG) in the differentiation of avian multipotent hematopoietic progenitors. We found that multipotent cells express high levels...
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