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Article

Suppression of the profilin-deficient phenotype by the RHO2 signaling pathway in Saccharomyces cerevisiae.

Genetics - 1 Oct 2000

Marcoux N, Cloutier S, Zakrzewska E, Charest P M, Bourbonnais Y, Pallotta D

Abstract excerpt

Profilin plays an important role in actin organization in all eukaryotic cells through mechanisms that are still poorly understood. We had previously shown that Mid2p, a transmembrane protein and a potential cell wall sensor, is an effective multicopy suppressor of the profilin-deficient phenotype in Saccharomyces cerevisiae. To better understand the role of Mid2p in the organization of the actin cytoskeleton, we...

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Identifiers

PMID: 11014808
DOI: 10.1093/genetics/156.2.579
PMCID: PMC1461282

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suppression of the profilin-deficient phenotype by the RHO2 signaling pathway in Saccharomyces cerevisiae.PMID 11014808Read ↗

Purification of profilin from Saccharomyces cerevisiae and analysis of profilin-deficient cells.Semantic proximity Read ↗

Overexpression of MID2 suppresses the profilin-deficient phenotype of yeast cells.Semantic proximity Read ↗

Rom1p and Rom2p are GDP/GTP exchange proteins (GEPs) for the Rho1p small GTP binding protein in Saccharomyces cerevisiae.Semantic proximity Read ↗

Profilin is required for Ca2+ homeostasis and Ca2+-modulated bud formation in yeast.Semantic proximity Read ↗

Geranylgeranyltransferase Cwg2-Rho4/Rho5 module is implicated in the Pmk1 MAP kinase-mediated cell wall integrity pathway in fission yeast.Semantic proximity Read ↗

Rgf1p is a specific Rho1-GEF that coordinates cell polarization with cell wall biogenesis in fission yeast.Semantic proximity Read ↗

Mutational analysis of yeast profilin.Semantic proximity Read ↗

Wsc1 and Mid2 are cell surface sensors for cell wall integrity signaling that act through Rom2, a guanine nucleotide exchange factor for Rho1.Semantic proximity Read ↗

The PH domain of the yeast GEF Rom2p serves an essential function in vivo.Semantic proximity Read ↗

A mutation in the Rho1-GAP-encoding gene BEM2 of Saccharomyces cerevisiae affects morphogenesis and cell wall functionality.Semantic proximity Read ↗

Negative functional interaction between cell integrity MAPK pathway and Rho1 GTPase in fission yeast.Semantic proximity Read ↗

Synthetic lethality screen identifies a novel yeast myosin I gene (MYO5): myosin I proteins are required for polarization of the actin cytoskeleton.Semantic proximity Read ↗

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