Article
Overexpression of MID2 suppresses the profilin-deficient phenotype of yeast cells.
Molecular microbiology - 1 Jul 1998
Marcoux N, Bourbonnais Y, Charest P M, Pallotta D
Abstract excerpt
Profilin-deficient Saccharomyces cerevisiae cells show abnormal growth, actin localization, chitin deposition, bud formation and cytokinesis. Previous studies have also revealed a synthetic lethality between pfy1 and late secretory mutants, suggesting a role for profilin in intracellular transport. In this work, we document further the secretion defect associated with the pfy1delta mutant. Electron microscopic...
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