Profilin is required for Ca2+ homeostasis and Ca2+-modulated bud formation in yeast.

doi:10.1007/s00438-013-0752-x

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Article

Profilin is required for Ca2+ homeostasis and Ca2+-modulated bud formation in yeast.

Molecular genetics and genomics : MGG - 1 Aug 2013

Yoshida Mitsunori, Ohnuki Shinsuke, Yashiroda Yoko, Ohya Yoshikazu

Abstract excerpt

A cls5-1 mutant of Saccharomyces cerevisiae is specifically sensitive to high concentrations of Ca2+, with elevated intracellular calcium content and altered cell morphology in the presence of 100 mM Ca2+. To reveal the mechanisms of the Ca2+-sensitive phenotype, we investigated the gene responsible and its interacting network. We demonstrated that CLS5 is identical to PFY1, encoding profilin. Involvement of...

Topics

Calcium
Cluster Analysis
Homeostasis
Models, Biological
Mutation
Profilins
Protein Binding
Protein Interaction Maps
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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Identifiers

PMID: 23708467
DOI: 10.1007/s00438-013-0752-x

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