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Article

Profilin is required for Ca2+ homeostasis and Ca2+-modulated bud formation in yeast.

Molecular genetics and genomics : MGG - 1 Aug 2013

Yoshida Mitsunori, Ohnuki Shinsuke, Yashiroda Yoko, Ohya Yoshikazu

Abstract excerpt

A cls5-1 mutant of Saccharomyces cerevisiae is specifically sensitive to high concentrations of Ca2+, with elevated intracellular calcium content and altered cell morphology in the presence of 100 mM Ca2+. To reveal the mechanisms of the Ca2+-sensitive phenotype, we investigated the gene responsible and its interacting network. We demonstrated that CLS5 is identical to PFY1, encoding profilin. Involvement of...

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PMID: 23708467
DOI: 10.1007/s00438-013-0752-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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