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Article

Frequency of cytochrome P450 3A4 variant genotype in transplant population and lack of association with cyclosporin clearance.

European journal of clinical pharmacology - 1 Aug 2000

Rivory L P, Qin H, Clarke S J, Eris J, Duggin G, Ray E, Trent R J, Bishop J F

Abstract excerpt

OBJECTIVE: Cytochrome P450 3A4 (CYP3A4) plays a vital role in the oxidative metabolism of many xenobiotics. Some recent reports have provided circumstantial evidence in support of an association between a genetic polymorphism (A-->G) in the 5'-flanking region (-290) of CYP3A4 and altered enzyme activity. We sought to determine whether genotyping patients for CYP3A4-G could assist with the dose optimisation of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11009048
DOI: 10.1007/s002280000166

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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