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Article

Mdr1 limits CYP3A metabolism in vivo.

Molecular pharmacology - 1 Oct 2000

Lan L B, Dalton J T, Schuetz E G

Abstract excerpt

We determined whether the drug efflux protein P-glycoprotein (Pgp) could influence the extent of CYP3A-mediated metabolism of erythromycin, a widely used model substrate for CYP3A. We compared CYP3A metabolism of erythromycin (a Pgp substrate) using the erythromycin breath test in mice proficient and deficient of mdr1 drug transporters. We first injected mdr1(+/+) mice with [(14)C]N-methyl erythromycin and...

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Share to Cytochrome P-450 CYP3A
Share to Cytochrome P-450 Enzyme Inhibitors
Share to Enzyme Activators

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

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Share to Oxidoreductases, N-Demethylating

Source

Identifiers

PMID: 10999959
DOI: 10.1124/mol.58.4.863

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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