Article
Familial adenomatous polyposis coli in South Africa--molecular basis and diagnosis.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde - 1 Jul 2000
Grobbelaar J J, Fortuin R, Scholtz C L, Zikind A, Langenhoven E, Wyllie A H, Bubb V J, Kotze M J
Abstract excerpt
OBJECTIVE: To determine the molecular basis and establish a routine molecular diagnostic service for familial adenomatous polyposis coli (FAP) families in South Africa. DESIGN: The coding region of the adenomatous polyposis coli (APC) gene in affected FAP kindreds was screened using heteroduplex analysis, single-strand conformation polymorphism analysis and the protein truncation test. SETTING: Department of...
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