Article
Association between diastolic blood pressure and variants of the endothelin-1 and endothelin-2 genes.
Journal of cardiovascular pharmacology - 1 Jan 2000
Brown M J, Sharma P, Stevens P A
Abstract excerpt
The genes for endothelin (ET) and their receptors are candidates for essential hypertension. Those for ET-1, ET-2 and the ET(A) receptor were selected for mutation scanning, and associated studies comparing untreated hypertensive patients and matched controls. A number of silent polymorphisms were found, resulting from a single nucleotide insertion or a single nucleotide substitution. There were no significant...
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