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Article

Association between the human glycoprotein PC-1 gene and elevated glucose and insulin levels in a paired-sibling analysis.

Diabetes - 1 Sept 2000

Gu H F, Almgren P, Lindholm E, Frittitta L, Pizzuti A, Trischitta V, Groop L C

Abstract excerpt

We studied whether there is an association between the single nucleotide polymorphism c.533A>C (K121Q) in the glycoprotein PC-1 gene and features of the metabolic syndrome in case-control and intrafamily association studies in 922 subjects from Finland and Sweden. No difference was observed in the Q allele frequency between control subjects and type 2 diabetic subjects (12.9 vs. 15.1%). The QK genotype was...

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PMID: 10969847
DOI: 10.2337/diabetes.49.9.1601

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Association between the human glycoprotein PC-1 gene and elevated glucose and insulin levels in a paired-sibling analysis.PMID 10969847Read ↗

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ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes in North Indians.Semantic proximity Read ↗

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The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121).Semantic proximity Read ↗

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