Article
The frequency of germ-line mutations in the breast cancer predisposition genes BRCA1 and BRCA2 in familial prostate cancer. The Cancer Research Campaign/British Prostate Group United Kingdom Familial Prostate Cancer Study Collaborators.
Cancer research - 15 Aug 2000
Gayther S A, de Foy K A, Harrington P, Pharoah P, Dunsmuir W D, Edwards S M, Gillett C, Ardern-Jones A, Dearnaley D P, Easton D F, Ford D, Shearer R J, Kirby R S, Dowe A L, Kelly J, Stratton M R, Ponder B A, Barnes D, Eeles R A
Abstract excerpt
Predisposition to prostate cancer has a genetic component, and there are reports of familial clustering of breast and prostate cancer. Two highly penetrant genes that predispose individuals to breast cancer (BRCA1 and BRCA2) are known to confer an increased risk of prostate cancer of about 3-fold and 7-fold, respectively, in breast cancer families. Blood DNA from affected individuals in 38 prostate cancer...
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