Extracellular phosphate ions cause apoptosis of terminally differentiated epiphyseal chondrocytes.

Abstract excerpt

Epiphyseal chondrocytes end their life cycle through apoptosis. While this event provides a mechanism for the removal of terminally differentiated cells from cartilage, agents that promote this physiological process have not been defined. To address this issue, using a cell culture technique that models events that take place in the growth plate, we asked the following questions: Can agents that promote...

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