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Article

The role of intracellular linkers in gating and desensitization of human pentameric ligand-gated ion channels.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 21 May 2014

Papke David, Grosman Claudio

Abstract excerpt

It has recently been proposed that post-translational modification of not only the M3-M4 linker but also the M1-M2 linker of pentameric ligand-gated ion channels modulates function in vivo. To estimate the involvement of the M1-M2 linker in gating and desensitization, we engineered a series of mutations to this linker of the human adult-muscle acetylcholine receptor (AChR), the α3β4 AChR and the homomeric α1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24849357
DOI: 10.1523/JNEUROSCI.5105-13.2014
PMCID: PMC4028499

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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