Catalase-less peroxisomes. Implication in the milder forms of peroxisome biogenesis disorder.

doi:10.1074/jbc.M006347200

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Article

Catalase-less peroxisomes. Implication in the milder forms of peroxisome biogenesis disorder.

The Journal of biological chemistry - 24 Nov 2000

Fujiwara C, Imamura A, Hashiguchi N, Shimozawa N, Suzuki Y, Kondo N, Imanaka T, Tsukamoto T, Osumi T

Abstract excerpt

We established a Chinese hamster ovary cell line having a temperature-sensitive phenotype in peroxisome biogenesis. This mutant (65TS) was produced by transforming a PEX2-defective mutant, Z65, with a mutant PEX2 gene, PEX2(E55K), derived from a patient with infantile Refsum disease, a milder form of peroxisome biogenesis disorder. In 65TS, catalase was found in the cytosol at a nonpermissive temperature (39...

Topics

ATP-Binding Cassette Transporters
Animals
CHO Cells
Catalase
Cricetinae
Fibroblasts
Humans
Membrane Proteins
Microbodies
Peroxisomal Biogenesis Factor 2
Peroxisomes
Phenotype
Temperature

Source

Open in PubMed

Identifiers

PMID: 10960480
DOI: 10.1074/jbc.M006347200

Genes

PEX2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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