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Article

Progesterone Receptor Isoform A But Not B Is Expressed in Endometriosis

1 Aug 2000

Abstract excerpt

We previously demonstrated that 17beta hydroxysteroid dehydrogenase type 2, the enzyme that inactivates estradiol to estrone, is expressed in luteal eutopic endometrium in response to progesterone but not in simultaneously biopsied peritoneal endometriotic tissue. This molecular evidence of progesterone resistance, together with the clinical observation of resistance of endometriosis to treatment with progestins,...

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Identifiers

PMID: 10946900
DOI: 10.1210/jc.85.8.2897

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