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Article

An intact SH3 domain is required for myosin I-induced actin polymerization.

The EMBO journal - 15 Aug 2000

Geli M I, Lombardi R, Schmelzl B, Riezman H

Abstract excerpt

The yeast type I myosins (MYO3 and MYO5) are involved in endocytosis and in the polarization of the actin cytoskeleton. The tail of these proteins contains a Tail Homology 2 (TH2) domain that constitutes a putative actin-binding site. Because of the important mechanistic implications of a second ATP-independent actin-binding site, we analyzed its functional relevance in vivo. Even though the myosin tail interacts...

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Identifiers

PMID: 10944111
DOI: 10.1093/emboj/19.16.4281
PMCID: PMC302045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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