Article
Breast cancer prognostic significance of a single nucleotide polymorphism in the proximal androgen response element of the prostate specific antigen gene promoter.
Breast cancer research and treatment - 1 May 2000
Bharaj B, Scorilas A, Diamandis E P, Giai M, Levesque M A, Sutherland D J, Hoffman B R
Abstract excerpt
Prostate Specific Antigen (PSA) expression by breast epithelial cells is associated with favorable breast cancer prognosis. In preliminary studies, we found that a nucleotide variation (G-->A) at position -158 in the androgen response element (ARE-1) of the PSA promoter was present in four out of 9 breast tumors examined and in a breast carcinoma cell line. We have now determined the nucleotide composition at...
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