Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neuropathological heterogeneity in Alzheimer's disease: a study of 80 cases using principal components analysis.

Neuropathology : official journal of the Japanese Society of Neuropathology - 1 Mar 2000

Armstrong R A, Nochlin D, Bird T D

Abstract excerpt

Three hypotheses have been proposed to explain neuropathological heterogeneity in Alzheimer's disease (AD): the presence of distinct subtypes ('subtype hypothesis'), variation in the stage of the disease ('phase hypothesis') and variation in the origin and progression of the disease ('compensation hypothesis'). To test these hypotheses, variation in the distribution and severity of senile plaques (SP) and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Apolipoprotein E4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoproteins E

Share to Data Interpretation, Statistical

Share to Genetic Heterogeneity

Share to Nerve Degeneration

Share to Neurofibrillary Tangles

Share to Plaque, Amyloid

Source

Identifiers

PMID: 10935434
DOI: 10.1046/j.1440-1789.2000.00284.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neuropathological heterogeneity in Alzheimer's disease: a study of 80 cases using principal components analysis.PMID 10935434Read ↗

Exploring the Genetic Heterogeneity of Alzheimer's Disease: Evidence for Genetic Subtypes.Semantic proximity Read ↗

Exploring the genetic heterogeneity of Alzheimer’s disease: Evidence for genetic subtypesSemantic proximity Read ↗

Atrophy subtypes and the ATN classification scheme in Alzheimer’s diseaseSemantic proximity Read ↗

AI System Using Unsupervised Learning to Discover Novel Subtypes in Alzheimer’s DiseaseSemantic proximity Read ↗

Heterogeneity and Factorial Structure in Alzheimer's Disease: A Cognitive Perspective.Semantic proximity Read ↗

Data-driven FDG-PET subtypes of Alzheimer’s disease-related neurodegenerationSemantic proximity Read ↗

Heterogeneity of Alzheimer’s disease: consequence for drug trials?Semantic proximity Read ↗

Graded multidimensional clinical and radiological variation in patients with Alzheimer’s disease and posterior cortical atrophySemantic proximity Read ↗

Multivariate analysis of laminar patterns of neurodegeneration in posterior cingulate cortex in Alzheimer's disease.Semantic proximity Read ↗

EEG abnormalities in early and late onset Alzheimer's disease: understanding heterogeneity.Semantic proximity Read ↗

Prominent Non-Memory Deficits in Alzheimer's Disease Are Associated with Faster Disease Progression.Semantic proximity Read ↗

Psychotic symptoms in Alzheimer disease: evidence for subtypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.