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Article

A novel leg-shaking Drosophila mutant defective in a voltage-gated K(+)current and hypersensitive to reactive oxygen species.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Aug 2000

Wang J W, Humphreys J M, Phillips J P, Hilliker A J, Wu C F

Abstract excerpt

1,1'-Dimethyl-4,4'-bipyridinium dichloride (methyl viologen; paraquat), an herbicide that causes depletion of NADPH and generates excessive reactive oxygen species (ROS) in vivo, has been used to screen for ROS-sensitive Drosophila mutants. One mutant so isolated, named quiver(1) (qvr(1)), has a leg-shaking phenotype. Mutants of the Shaker (Sh), Hyperkinetic (Hk), and ether a go-go (eag) genes, which encode...

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PMID: 10934243
PMCID: PMC6772572

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