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Article

Late-onset neurodegenerative diseases--the role of protein insolubility.

Journal of anatomy - 1 May 2000

Johnson W G

Abstract excerpt

Recently, mutations of the alpha-synuclein gene were found to cause dominantly inherited Lewy-body Parkinson's disease (PD) and alpha-synuclein was identified as a major component of the Lewy body. However, the cause of the common form of PD, with a multifactorial rather than autosomal dominant inheritance pattern, remains unknown. Alpha-synuclein precipitates slowly and apparently spontaneously at high...

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Identifiers

PMID: 10923991
DOI: 10.1046/j.1469-7580.2000.19640609.x
PMCID: PMC1468101

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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