The micromechanical environment of intervertebral disc cells: effect of matrix anisotropy and cell geometry predicted by a linear model.

Abstract excerpt

Cells of the intervertebral disc exhibit spatial variations in phenotype and morphology that may be related to differences in their local mechanical environments. In this study, the stresses, strains, and dilatations in and around cells of the intervertebral disc were studied with an analytical model of the cell as a mechanical inclusion embedded in a transversely isotropic matrix. In response to tensile loading...

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