Article
Novel mechanism of surface catalysis of protein adduct formation. NMR studies of the acetylation of ubiquitin.
The Journal of biological chemistry - 13 Oct 2000
Macdonald J M, Haas A L, London R E
Abstract excerpt
Reactivity of surface lysyl residues of proteins with a broad range of chemical agents has been proposed to be dependent on the catalytic microenvironment of the residue. We have investigated the acetylation of wild type ubiquitin and of the UbH68N mutant to evaluate the potential contribution of His-68 to the reactivity of Lys-6, which is about 4 A distant. These studies were performed using [1-(13)C]acetyl...
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