Article
NMR study of the sites of human hemoglobin acetylated by aspirin.
Biochimica et biophysica acta - 13 Jul 1999
Xu A S, Macdonald J M, Labotka R J, London R E
Abstract excerpt
Acetylation of hemoglobin by aspirin and other acetylating agents has been used to generate hemoglobin analogs with altered structural and functional properties, and may prove useful in the treatment of sickle cell disease. We have studied the acetylation of human hemoglobin using [1'-(13)C]acetylsalicylic acid in combination with two-dimensional HMQC and HSQC NMR analysis. The spectra of the acetylated...
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