Article
Differential protein expression in phenotypic variants of Streptococcus pneumoniae.
Infection and immunity - 1 Aug 2000
Overweg K, Pericone C D, Verhoef G G, Weiser J N, Meiring H D, De Jong A P, De Groot R, Hermans P W
Abstract excerpt
Streptococcus pneumoniae undergoes spontaneous phase variation resulting in opaque and transparent colony forms. Differences in colony opacity correlate with differences in virulence: the transparent variants are more capable of colonizing the nasopharynx, whereas the opaque variants show increased virulence during systemic infections. To gain insight into the pathogenesis of pneumococcal disease at the molecular...
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