Article
Role of fimbriae expressed by nontypeable Haemophilus influenzae in pathogenesis of and protection against otitis media and relatedness of the fimbrin subunit to outer membrane protein A.
Infection and immunity - 1 May 1994
Sirakova T, Kolattukudy P E, Murwin D, Billy J, Leake E, Lim D, DeMaria T, Bakaletz L
Abstract excerpt
Nontypeable Haemophilus influenzae is a primary pathogen in both acute otitis media (OM) and chronic OM, yet the pathogenesis of this disease is not fully understood. Although fimbriae have been observed on all clinical OM isolates examined to date, their role in pathogenesis remains unclear. Therefore, the gene which codes for the fimbrial subunit protein (fimbrin) in nontypeable H. influenzae 1128 was isolated,...
Topics
- Amino Acid Sequence
- Animals
- Bacterial Outer Membrane Proteins
- Base Sequence
- Chinchilla
- Cloning, Molecular
- Fimbriae, Bacterial
- Haemophilus influenzae
- Immunization, Passive
- Membrane Glycoproteins