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Article

Sexual dimorphism in diverse metazoans is regulated by a novel class of intertwined zinc fingers.

Genes & development - 15 Jul 2000

Zhu L, Wilken J, Phillips N B, Narendra U, Chan G, Stratton S M, Kent S B, Weiss M A

Abstract excerpt

Sex determination is regulated by diverse pathways. Although upstream signals vary, a cysteine-rich DNA-binding domain (the DM motif) is conserved within downstream transcription factors of Drosophila melanogaster (Doublesex) and Caenorhabditis elegans (MAB-3). Vertebrate DM genes have likewise been identified and, remarkably, are associated with human sex reversal (46, XY gonadal dysgenesis). Here we demonstrate...

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PMID: 10898790
PMCID: PMC316782

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Sexual dimorphism in diverse metazoans is regulated by a novel class of intertwined zinc fingers.PMID 10898790Read ↗

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ZNF423 orthologs are highly constrained in vertebrates but show domain-level plasticity across invertebrate lineagesSemantic proximity Read ↗

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A panoramic view of the expression and function of the Doublesex/DMRT gene family in <i>C. elegans</i>Semantic proximity Read ↗

Evolutionary dynamics of the DM domain gene family in metazoans.Semantic proximity Read ↗

Regulation of sex-specific differentiation and mating behavior in C. elegans by a new member of the DM domain transcription factor family.Semantic proximity Read ↗

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