Article
[Diagnosis of neurodegenerative disease by mass spectrometry].
Rinsho byori. The Japanese journal of clinical pathology - 1 May 2000
Kishikawa M
Abstract excerpt
We analyzed wild-type and variant transthyretins (TTRs) by mass spectrometry and reported that all TTR preparations demonstrated free TTR, TTR conjugated with thiol compounds and several minor components. We previously described a component with a molecular mass 80 Da larger than free TTR, which was proven to be TTR conjugated with bisulfite. The amyloid fibril formation of purified TTR was monitored by the...
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