Article
Characterization of transthyretin mutants from serum using immunoprecipitation, HPLC/electrospray ionization and matrix-assisted laser desorption/ionization mass spectrometry.
Analytical chemistry - 15 Jan 1999
Théberge R, Connors L, Skinner M, Skare J, Costello C E
Abstract excerpt
A mass spectrometry approach for the detection and identification of variants of the plasma protein transthyretin (TTR) is presented. The single amino acid substitutions found in TTR are closely associated with familial transthyretin amyloidosis (ATTR), a hereditary degenerative disease. A defini...
Topics
- Amino Acid Sequence
- Amyloidosis
- Chromatography, High Pressure Liquid
- Humans
- Mass Spectrometry
- Methionine
- Molecular Sequence Data
- Mutation
- Prealbumin
- Precipitin Tests
- Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
- Valine