Article
Transthyretin mass determination for detection of transthyretin familial amyloid.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2009
O'Brien John F, Bergen H Robert
Abstract excerpt
The concentration range of plasma proteins exceeds the dynamic range of any single analytical method. It has been estimated that the concentration range of serum proteins exceeds ten orders of magnitude (1). Because of this, prior immunoselection of even abundant proteins facilitates the relative nonquantitative observations required to show structural abnormality in primary or in posttranslational structure....
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