Article
Mapping of a gene for severe pediatric gastroesophageal reflux to chromosome 13q14.
JAMA - 19 Jul 2000
Hu F Z, Preston R A, Post J C, White G J, Kikuchi L W, Wang X, Leal S M, Levenstien M A, Ott J, Self T W, Allen G, Stiffler R S, McGraw C, Pulsifer-Anderson E A, Ehrlich G D
Abstract excerpt
CONTEXT: Gastroesophageal reflux (GER) has not previously been widely regarded as a hereditary disease. A few reports have suggested, however, that a genetic component may contribute to the incidence of GER, especially in its severe or chronic forms. OBJECTIVE: To identify a genetic locus that cosegregates with a severe pediatric GER phenotype in families with multiple affected members. DESIGN: A genome-wide scan...
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